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Biography

We investigate the impact of RNA nucleotide modifications in RNA-protein interactions.

Biography

Biography

We investigate how the neuropeptides oxytocin and vasopressin contribute to the neural regulation of behavior.

Biography

We investigate the molecular and biological processes governing the development of brain malignancies, including primary (e.g., glioblastoma) and metastatic (tumors originating from other locations in the body, such as breast cancer) brain cancers. Our goal is to develop novel immunotherapeutic strategies for patients with brain cancers.

Biography

Biography

We investigate neurodevelopment in the context of reproduction and stress regulation. Our focus is on the impact of microcystin toxins, that are found in algae contaminated freshwater used for drinking water. We use a variety of techniques that include standard immunohistological techniques and genomics to name a view. 

Biography

Biography

Biography

We investigate and develop new methods and tools to record neurons in the brain using nonlinear microscopy and protein sensors. Our goals are to better understand the role of brain circuits and the efficacy of novel neuroprotective treatments in rodent models of neurodegenerative and neurological conditions.

Biography

We investigate neuroprotective strategies, and the role of oxidative stress and bioenergetic stress in neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease as well as in psychiatric illnesses such as schizophrenia and posttraumatic stress disorder. We investigate the neurochemical mechanisms of amphetamine neurotoxicity, and the mechanism of action of novel and atypical antipsychotics.

Biography

We investigate the tumor suppression activity of an eIF2-associated glycoprotein, p67 in human cancer cells and in mice model.
 

Biography

We investigate how microglia facilitate normal brain function and regulate neuroimmune responses when the brain is compromised. We combine cutting-edge imaging, with molecular, cellular and genetic approaches to study the interactions between blood vessels, neurons, and glia, and understand how their functional and structural relationships change between health and disease.

Biography

We investigate early mechanisms of Alzheimer’s disease. Our goal is to discover how disruption of basic functions of the body can drive disease processes that destroy the brain. We study how integrin protein dysfunction is an early driver of AD pathology, and how AD pathology affects visual system signaling. 

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We investigate diabetes, cardiovascular diseases, inflammation, and stem cell-based gene therapy.

Biography

We investigate the mechanisms underlying neurological disability in central nervous system diseases like multiple sclerosis. The laboratory employs modern techniques to address hypothesis driven studies using human samples, animal models and in vitro methods.

Biography

My laboratory’s research focuses on comparative neurobiology with an emphasis on aging, neuroinflammation, and neurodegenerative diseases (e.g., Alzheimer’s and Parkinson’s diseases). Using an evolutionary perspective, we investigate neurological variances across species, particularly nonhuman primates, as possible mechanisms of humans’ unique vulnerability to aging and neurodegeneration and human-specific cognitive specializations.

Dr. Edler's Lab Website

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Biography

We investigate how obesity, diabetes, and metabolic syndrome affect the liver-gut-brain axis. We focus our studies on bile acid physiology and receptor signaling within the context of alcoholic and metabolic liver disease.

Biography

In my lab, we are using electrophysiological and behavioral approaches to study the auditory system. Electrophysiological approaches include but are not limited to extracellular and intracellular recordings of single-neuron responses at different levels of the central auditory system as well as non-auditory brain structures in unanesthetized animals. Behavioral approaches are mainly focused on tinnitus or hearing loss assessments in laboratory animals using pre-pulse inhibition of the acoustic startle reflex. Our lab was the first to develop a tinnitus mouse model which is widely used in the field of tinnitus research.

Biography

Biography

Biography

We investigate the effects of environmental stressors on the human thermal, metabolic and immunologic responses. 

Biography

We investigate how the heart balances oxygen and nutrient delivery with its demands, aiming to understand key regulators that link oxygen supply with cardiac function. Our research focuses on identifying dysregulated mediators in disease and exploring cardioprotective mechanisms to discover therapeutic targets for cardiovascular disease.

Biography

Biography

We investigate the evolution and function of body patterning genomic loci in vertebrates.

Biography

The focus of our research group is the use of liquid crystals (LCs) and Liquid Crystal Elastomers (LCEs) for biological applications.

Biography

Biography

We investigate interactions between the nervous system and immune systems that lead to alterations in behavior and cognitive functioning. We utilize in vivo and ex vivo approaches to investigate how environmental stressors and inflammatory stimuli impact mood, motivation, and learning.

Dr. Johnson's Lab Website

Biography

Our laboratory applies high-throughput unbiased system biology approaches, i.e. metabolomics and proteomics to understand the pathogenesis of obesity-associated metabolic diseases, including nonalcoholic fatty liver disease (NAFLD) and diabetes, and their cardiovascular complications. Our group helped to develop the heavy water-based metabolic labeling approach for global proteome dynamics studies, which are currently extensively used by multiple research labs around the world.  NAFLD and type 2 diabetes (T2D) afflict one-third of the US’s population. While T2D is treatable, to date, no reliable therapies exist for NAFLD, despite it being associated with significant morbidity and mortality. There is growing evidence that the dysfunction of mitochondria (the part of a cell that converts food into energy) plays a crucial role in disease propagation. Our recently funded proposal will develop a stable isotope-coupled mass spectrometry method to understand the link between metabolic disorders and Alzheimer’s disease. The method developed in this study can be used in other diseases, including diabetes, neurodegeneration, cancer, etc. In collaboration with NIH we will benchmark this technique for use by other investigators.

Biography

Biography

We investigate the cellular and molecular mechanisms underlying the construction of the brain and functional neural circuitry, particularly genesis, positioning and connectivity of neurons in the brain. These processes are essential for communication across the brain and for generating cognitive, social and emotional behaviors.

Dr. Kim's Lab Website

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We investigate the biophysics or protein-lipid interactions and the physical chemistry of membrane lipids. Using home-built instrument we currently investigate how proteins interact with intracellular lipid droplets. We focus on the perilipins but also compare results with unrelated neutral lipid droplet binding proteins, for example apoA1 and fibrillins.

Dr. Kooijman's Lab Website

Biography

We investigate immune-based therapies for cancer. This entails study of the tumor microenvironment, and how to alter it to foster immune responses capable of eliminating malignancies. 

Dr. Koski's Lab Website

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Biography

We investigate genetic basis of organismal response to novel environments. Such response generally occurs through genetic adaptation, phenotypic plasticity or combination of these two processes. We are particularly interested in exploring the relative roles of genetic adaptation and phenotypic plasticity that underly a trait evolution. We integrate a variety of interdisciplinary approaches, including comparative ‘omics’ (Genomics, Transcriptomics, Epigenomics, Metagenomics and Metabolomics) and Eco-physiology to uncover the molecular basis underlying the processes of adaptive evolution. We work with a variety of non-model systems that includes birds and mammals.

Biography

We investigate the protein complexes and mechanisms that regulate genome organization throughout the cell cycle, and we study the consequences of disrupting DNA organization during development and for disease pathogenesis. We also study the role of retrotransposons in DNA organization, development and disease pathogenesis.

Biography

We investigate the roles of the brain barriers (meninges, blood brain barrier and choroid plexus) in normal and pathological brain function. We particularly focus on immune-vascular interaction during neurodevelopment and neurodegeneration.

Biography

Biography

Biography

We investigate mechanobiology processes at the single-molecular, molecular assembly, and cellular level. We use optical tweezers to reveal interactions between individual nucleic acid structures and motor proteins (e.g. polymerases) from mechanical perspectives. At the cellular level, we strive to probe the effect of molecular machineries such as protein aggregates and organelles on cell mechanics such as migrations and divisions.

Biography

Biography

Biography

We investigate age-related changes during middle and old age in the auditory circuits. Our primary tools of investigation are transmission electron microscopy, tract-tracing, single molecule fluorescent hybridization, and immunohistochemistry.

Biography

We investigate circadian rhythms of feeding and activity and how they interact with environmental stimuli.  We also study how disruption of circadian rhythms alters reproductive cycles.
Dr. Mintz's Lab Website

Biography

We investigate water and ion balance, macromolecular crowding, cell stress and death, and new microscopic techniques.

Dr. Model's Lab Website

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We investigate cells in the brain that regulate gonadotrophin-releasing hormone (GnRH) neurons, the final output cells in a large neural network controlling fertility. Our research is focused on identifying changes in these networks that underlie the development of common forms of infertility, such as polycystic ovary syndrome. 

Biography

We investigate the hypothalamic neuronal circuits that control that activity of gonadotropin-releasing homrone neurons, gonadotropin hormone secretion, gonadal function and fertility. Our research has focused in the past few years on how the central circadian clock influences the neuroendcorine control of ovulation in females.

Dr. Mou's Lab Website

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We investigate how the brain modulates skeletal muscle thermogenesis—heat generation in muscle—and how this impacts energy balance and body weight. 
Dr. Novak's Lab Website

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Biography

We investigate the molecular mechanisms that drive pathology in Dementia with Lewy bodies (DLB), Parkinson’s Disease (PD), and Alzheimer’s Disease (AD), with the eventual goal of developing therapeutics that block or slow disease progression.

Biography

Biography

We are a bioinformatics lab, studying patterns of RNA editing in the context of host-pathogen interactions, and how RNA editing changes in brain health and disease. We currently focus on the role of ADAR editing changes in neurodegenerative and neuropsychiatric disorders, including Parkinson’s and Alzheimer diseases, and mental health disorders. 

Biography

Our lab develops translational therapies for regeneration and recovery after spinal cord injuries and discovers drugs to stop glioblastoma progression in mice, aiming to advance these into clinical trials

Biography

We investigate the neuroanatomical bases of what it means to be human. We use a comparative approach to understanding how the human brain differs from other species, including our susceptibility to neuropathological processes such as Alzheimer's disease.

Dr. Raghanti's Lab Website

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Biography

We investigate the inflammatory component of Alzheimer's disease using various mouse models. We are interested in microglia, the brain's resident immune cells, as well as components of the circulating peripheral immune system and their interactions with microglia, as well as how these cells may respond differently based on sex. 

Biography

We investigate how aging and neurological disorders limit movement in humans. Our current research examines the benefits of exercise and rehabilitation training on motor function in individuals with Parkinson's disease. Research methods used in human subjects research include movement assessment/evaluation, electromyography and Functional Near-Infrared Spectroscopy.  

Dr. Ridgel's Lab Website

Biography

Biography

Our lab develps DNA-based nanoscale lipid bilayer mimetics for the structure determination of membrane proteins by cryo-electron microscopy. Moreover, we study mechanical properties of tightly bent DNA that govern biological processes including transcription, gene regulation and packing in the nucleus.

Dr. Schmidt's Lab Website

Biography

We investigate brain circuits that modulate how we hear in different environments, during growth and aging, and after damage to the ear or the brain. We use sophisticated neural tracing methods to characterize neural circuits in rodents so we can understand how those circuits contribute to hearing.
 

Biography

We investigate the neural basis of dysautonomia in autism spectrum disorder. Our lab uses systems and behavioral neuroscience to define the brain-body connection. The goal of this work is to transform how we diagnose and treat neurodevelopmental disabilities and other neuropsychiatric diseases.

Biography

My research laboratory primarily focuses on drug design and discovery studies targeting beta-lactam drug resistance (DR) systems and drug neurodegenerative disorders. Additionally, we emphasize research on disease mechanisms. The ultimate goal is identifying unprecedented drug targets and pathogenic pathways, developing effective therapeutic strategies, and designing new lead compounds to overcome drug resistance and neurodegenerative disorders. 
Our research team has a well-balanced research background and laboratory environments in medicinal chemistry/cell biology experiments and fluorescence-based in-vivo testing systems, including extensive expertise in computer-aided drug design (CADD) study techniques.

Biography

Biography

We investigate microbiome-host interactions in the oral cavity, particularly in the setting of gum disease (one of the most prevalent inflammatory conditions worldwide) and comorbidities such as diabetes and oral cancer. We are specifically interested in how host diet and inflammation regulate microbe-microbe interactions within the oral microbiome and how these interactions in turn impact host fitness. Long-term, our goal is to translate our findings into more targeted microbiome-directed therapeutics.
 

Biography

Biography

We investigate major morphological transitions in evolution, focusing on whale evolution.  Our samples include fossil Eocene whales, as well as anatomical samples of modern bowhead and beluga whales.

Biography

We investigate how microbial symbionts shape the ecology and evolution of their vertebrate hosts. Our lab uses a combination of multi-omic techniques, germ-free animal experiments, and natural history studies to determine how intestinal microorganisms affect the phenotypes of wild vertebrates in nature. 

Biography

We investigate mechanisms by which emotional brain centers such as the amygdala interact with the auditory system to establish the meaning of speech and other social vocalizations. We seek to relate these mechanisms to acoustic communication behavior and to disorders resulting in altered emotional responses to speech.

Biography

We investigate the inflammatory and neurodegenerative disease multiple sclerosis. Specifically, we focus on how immune signals modulate glia function to influence both pathophysiology and repair. 

Biography

We investigate cellular properties that underlie the ability of neuronal ensembles to extract and encode information and their experience-dependent maturation using brainstem circuits that compare information between the two ears that are critical for sound localization and may be disrupted in children with central auditory processing disorder. 

Biography

We investigate gait, locomotor biomechanics, and motor development in primates and other mammals.

Biography

We investigate the design and development of innovative metal-based chemical tools and their subsequent application in biological systems with a long-term goal of improving cancer therapy.